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In addition, GSH cannot directly enter the brain due to the existence of the blood-brain barrier (BBB)

While some people notice a "glow" within a few weeks due to reduced oxidative stress, visible changes in skin pigmentation typically take 3 to 6 months
(Shizuoka, Japan)

[DOI] [PMC free article] [PubMed] [Google Scholar] 191.Arnsten A.F.T., Woo E., Yang S., Wang M., Datta D

Thus, this epigenetic alteration is now considered as a cancer biomarker but could as well play a driving role in multistep cancer development, especially well documented in prostate cancer development
