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Therefore, it is plausible that thyroid hormones can upregulate HO-1 expression via ROS signaling
1996;271:C1424C1437

Nrf2 is expressed the majority of cell types, where it is anchored in the cytosol by an inhibitory protein, Kelch-like ECH-associated protein (Keap1)

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J Recept Signal Transduct Res 2015;35:329-39