Decoding ferroptosis for cancer therapy
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Description
In some cases, there is also an increased risk of cancer, especially with metals like arsenic, which are known carcinogens
Plasma half-life estimates range from 30-60 minutes based on limited animal and human studies, though systematic pharmacokinetic characterization in humans has not been published
NADH can bind to the NADH/ADP binding site and enhance the inhibitory effect of GTP on GDH activity by slowing down the release of NAD(P)H, an oxidative product of glutamate
doi: 10.1016/j.diabres.2018.08.010
(PubMed) Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J
