glutamine glutathione depletion Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation Frontiers | Preclinical investigations of

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Lipidomic analysis revealed that GSH depletion significantly decreased levels of neutral lipids, including diacylglycerols (DAGs), triacylglycerols (TAGs), and cholesterol esters (CEs), while GSH depletion increased levels of sphingolipids and phospholipids (Figure 4, B and C, and Supplemental Figure 3, AC), many of which have been shown to improve hepatic steatosis (26)

A Phase I clinical trial for drug-resistant epilepsy has evaluated the safety and preliminary efficacy of MSC transplantation, reporting good tolerability and no serious adverse events, thereby supporting MSCs as a promising therapeutic strategy for EDC (Hlebokazov et al., 2021)

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This fundamental mechanism underpins its efficacy in repairing a wide array of tissues, from gut mucosa and muscle tendons to neural tissue