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117 Additionally, to improve patient compliance, it is crucial to extend the drugs half-life

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The results of the pharmacokinetic study correlated remarkably well with the dog study, confirming the selective absorption window for hydrocortisone and verifying critically that sustained-release functionality was indeed not necessary as the intrinsic dissolution rate of hydrocortisone was already sufficiently slow to maintain an absorption input rate that was commensurate with the required target pharmacokinetic profile

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instead, GLP- 1 receptor activation stimulates EGF receptor signaling [20]