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Typically, weekly sessions are held initially, followed by bi-weekly or monthly maintenance sessions

doi: 10.3389/fphys.2024.1415037, 59

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However, the short lifespan of effector T cells remains a major limitation of CAR-T therapy (168, 169)

PCOS symptoms like the imbalance in the hypothalamic-pituitary-ovarian axis secretion, androgen production, and insulin resistance are likely exacerbated by the hyperandrogenism associated with PCOS which converts macrophages to the M1 state and raises cytokine levels [31]