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Ndusf1 can be S-glutathionylated on Cys 531 and Cys 704 in bovine heart mitochondria which lowers its activity (Hurd et al., 2008)

2009;124 doi: 10.1016/j.jaci.2009.05.038

Despite mitochondrial immaturity, plays an important role in mitochondrial homeostasis by selectively eliminating defective mitochondria ( via OXPHOS but more pronounced glycolysis-based energy flux ( Figure 2 Specific transcriptional fingerprints can also be used to identify an iPSC's metabolic profile

Several enzymes use glutathione in reaction mechanisms and fulfill a variety of protective, defensive, synthetic, or signaling roles in cellular metabolism

GSSG cannot act as an antioxidant and must first be converted back to GSH