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In hereditary spherocytosis (HS), the exposure of PS is more prevalent compared to - and -thalassemia, particularly in younger erythrocytes [414]

CAFs constitute a major stromal component, accounting for over 50% of the TME in certain malignancies [141]

Several factors cause this: Lower stomach acid production [6] Less intrinsic factor [6] Interference from medications (especially proton pump inhibitors and metformin) [6] Atrophic gastritis affects 8-9% of adults over 65, which makes nutrient absorption even harder [7]

Key studies published in 2020 demonstrate that an impaired intestinal barrier precedes clinical diagnosis of inflammatory bowel disease (IBD) by years

Cancer 124 , 192202 (2018)