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A sustained activation of the ERK pathway maintains macrophage survival under hyperoxia by reducing the action of the pro-apoptotic protein Bcl-2 by downregulating specific phosphatases [319]
Depletion of high-content CD14(+) cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing
doi: 10.1080/19390211.2023.2301366 73
A systematic review examining these trials found modest positive effects in certain patient groups
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