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The intranasal route offers advantages for mood-related applications because it bypasses the blood-brain barrier more efficiently, delivering the peptide directly to central nervous system targets

However, in vitro analysis revealed that phosphorylation of Ser40 has a minimal effect on the binding of NRF2 to KEAP1, and therefore the importance of this modification is currently unclear (98)

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94 In a Phase 3 trial, the median PFS for the pyrotinib plus capecitabine group was 11.1 months, which was significantly longer than that of only 4.1 months for the placebo group

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