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Description
A systematic review of randomized controlled trials found that high-dose oral vitamin B12 (2000 g daily) was as effective as intramuscular injections in increasing serum vitamin B12 levels and improving hematological and neurological outcomes in deficient patients

In the UK, this is included as a special warning and precaution in the Summary of Product Characteristics (SmPC) rather than a formal contraindication
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Patients on chronic hemodialysis have a 10 to 15 fold higher risk of death than the native population, mostly due to cardiovascular disease development (CVD)

Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE
