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It doesn't override thermodynamics

Figure 3 GSTP Enters the Nucleus and Interacts with HMGB1 in Response to LPS Stimulation The immunoblotting analysis and confocal microscopy observation showed that nuclear GSTP protein level can be detected within 5 min after LPS treatment and peaked at 1 h (Figures 4AC)
doi: 10.1074/jbc.M109.070201 301 WichA.TarczewskaA.OyharA.OrowskiM
doi: 10.1146/annurev.arplant.57.032905.105421

A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions
