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Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)

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These effects are frequently characterized in controlled laboratory settings

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Naunyn Schmiedebergs Arch Pharmacol 379:385388

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G.LiuH.SunK.et al (2017)

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In contrast, supplements that contain multiple B-complex vitamins provide 50 to 500 mcg of vitamin B12

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