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Furthermore, Nrf2 can promote the removal of damaged or misfolded proteins by regulating proteasome activity (69, 87, 88)

In a large meta-analysis of 41 randomized controlled trials including 2,768 patients with systemic inflammatory response syndrome or sepsis, late application (more than 24 hours after the onset of symptoms) of N-acetylcysteine was associated with cardiovascular instability (31)

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