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However, this heightened production may be associated with diminished functionality and efficiency, likely due to alterations in NET composition and impaired clearance mechanisms [166]

They concluded that elevated PAI-1 levels can lead to a variety of kidney disease

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10.1002/cphy.c130024 [DOI] [PMC free article] [PubMed] [Google Scholar] Ling S., Li J., Shan Q., Dai H., Lu D., Wen X., et al