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10.1016/j.exer.2016.12.008 361 SuiX.ChenR.WangZ.HuangZ.KongN.ZhangM.et al (2013)

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found that LPS stimulation led to an approximately 30-fold accumulation of succinate in mouse bone marrow-derived macrophages (BMDMs), which in turn specifically promoted the transcription and expression of IL-1 by inhibiting prolyl hydroxylase (PHD) and stabilizing HIF-1 ( During macrophage metabolic reprogramming, amino acid metabolism does not operate independently, but is embedded within the overall metabolic network
