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Hence, it can exist in various states, depending on the local redox environment and the presence of oxidizing and reducing agents

Besides, MTX treatment causes DNA strands to break in intestinal epithelial cells that proliferate quickly (Sonis 2004) and induces oxidative stress (El-Sheikh et al

Under physiologic conditions of increased ROS, the NRF2 stress response promotes an antioxidant network that will scavenge and clear ROS

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