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Patients with active malignancy, untreated hypothyroidism, or known hypersensitivity to sermorelin or any component of the formulation should discuss risks with their provider before starting therapy

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Though causation has not been established between vitamin B12 deficiency and depression, it has been found to be involved with many neurochemical pathways that potentially lead to this mental health disorder

These include: Metformin use : Metformin impairs vitamin B12 absorption in the intestine

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