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310 The discovery that some sirtuins, including mammalian SirT6 311 and Sir2A from Plasmodium falciparum (312) selectively hydrolyze long-chain acyl groups from the side chains of internal lysine residues suggests that this reaction is important enough in vivo for the evolution of protective mechanisms

Arrais, R.B.T

[DOI] [PubMed] [Google Scholar] 111.Bjrkegren J., Karpe F., Milne R.W., Hamsten A

Abstract The androgen receptor (AR) signalling pathway has been intensively studied in the context of prostate cancer, where androgen deprivation therapy is part of the standard of care for metastatic disease