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Additionally, HIF-1 activates increased EPO expression, to induce expression of brain-derived neurotrophic factor (BDNF) and promote hippocampal neurogenesis ( Shh signaling pathway The sonic hedgehog (Shh) signaling pathway plays an important role in endogenous neurogenesis (38) and can play a neuroprotective role in ischemia-exposed brain injury through the activation of pathway proteins (39)
S.VermettenE.et al (2008)
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10.1016/j.chembiol.2017.08.013 20 HanZ.-J.FengY.-H.GuB.-H.LiY.-M.ChenH
After all necessary data was collected for the Morris water maze test, the mice were euthanized and the brain tissue was dissected
