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The appearance of the vessels was assessed (see also Figure 1) between (1) the last arcade proximal to first ligation (arcade 0) and the first arcade distal to the ligation (or to the previous ligation) (arcade 1) (0-1, Figure 2, Figures 5-8, and Figures 21 and 22)

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Additionally, navitoclax is almost impenetrable to the blood brain barrier, thus, the current drugs are not able to reach the brain parenchyma (67)