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Third, these compounds often exhibit poor stability, degrading quickly under physiological conditions, which reduces their efficacy
[PubMed: 8175957] 117
It not only supports the bioenergetic and biosynthetic demands of tumors, but also profoundly influences metastatic potential and therapeutic response
Next, we tested whether overexpression of RNR alone could restore normal ferroptosis sensitivity in cells where the p53/p21 pathway was activated
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