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2.5.1.1 Small molecules analysis Compounds in the samples analyzed between 2020 and 2023 were identified using a high-performance liquid chromatograph (Ultimate 3,000 system from Dionex, Thermo Fisher Scientific, Waltham, MA, United States) coupled with a high-resolution micrOTOF-QII hybrid mass spectrometer (Bruker Daltonik, Bremen, Germany)

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

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IV Vitamin Infusions can be a one time treatment before or after an event, or you can come in bi-weekly