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(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

Some researchers use exfoliating treatments periodically to further improve absorption

B12 has a very low toxicity, so large amounts are not considered dangerous
It ensures tissues get enough oxygen
