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Because in M1 macrophages there is a reduced expression of the TCA cycle enzyme isocitrate dehydrogenase, citrate increases in mitochondria and is shuttled to the cytosol to be used for lipid synthesis (66)
Nasca D, Zurria G, Aguglia E
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Khode, Evaluation of effect of different disposable infection control barriers on light intensity of light-curing unit and microhardness of composite An in vitro study, J Conserv Dent 20(3) (2017) 180-184
So just like with the master study, our first step is to frame the line work with the typical angular marks
