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In todays sanitized, modern world, the water supply is commonly chlorinated to kill off any bacteria

10.2174/13816128130111 65 StupnisekM.FranjicS.DrmicD.HrelecM.KolencD.RadicB.et al (2012)

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To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)