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demonstrated increased GSH levels as well as decreased nuclear factor kappa B activity corresponding with overall decreased oxidative stress on the cardiomyocytes and decreased myocyte apoptosis [47]

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The PI3K pathway as drug target in human cancer

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Beyond its role in mediating astrocyte migration, the Gpr183/oxysterol has also been implicated in astrocyte migration

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Single-cell RNA sequencing studies have revealed that bioactive compounds can induce cell-type-specific transcriptional responses in neurons, astrocytes, and microglia, highlighting the complexity of nutrigenomic effects in the post-stroke brain (189)

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