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T2DM mice treated with ginseng polypeptide (GP) on a high-sugar and high-fat diet (including streptozotocin (STZ)) showed that GP could play a hypoglycemic role by restoring the SCFA-producing microbiota in the intestine, and enriched the microflora closely related to lipid metabolism, oxidative stress and inflammatory response, such as desalted bacilli, Bifidobacterium spp., and bacteroides (128)

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Both intermittent dosing schedules (injections on specific days) and continuous daily administration showed benefits, suggesting some flexibility in protocol design

But like any medical treatment, they come with both benefits and risks