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10.1007/s00018-016-2147-8 Cell Mol

While the precise contribution of each pathway and the specific post-translational modifications on FOXO1 were beyond the scope of this study, it is plausible that KRAS-driven alterations in PI3K/AKT/mTOR, ERK and PKA signalling not only modulate FOXO1 functional state but also drive its mRNA levels through FOXO1 transcriptional autoregulation (Shen et al, 2014)

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Store unreconstituted vials at -20C for long-term, or refrigerated at 2-8C for short-term use

10.1126/scisignal.2004870 244 MahalingamD.MitaM.SarantopoulosJ.WoodL.AmaravadiR