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In agreement, ASMase knockout mice exhibited enhanced hepatotoxicity and liver damage after APAP overdose, while hepatocytes challenged with U18666A, which induces the accumulation of cholesterol in lysosomes, sensitized hepatocytes to APAP-mediated cell death

When persistent, neuropathy can disrupt daily lives in multiple ways, such as making walking unsteady due to numbness, causing difficulty gripping objects, heightening pain sensitivity to even light touches, interfering with sleep, and leading to fatigue and mental exhaustion

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doi: 10.1016/j.cell.2023.05.003 195 ChenBWangLXieDWangY

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Castleton P.E., Deluao J.C., Sharkey D.J., McPherson N.O