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This co-delivery mechanism enables a unique two-phase action: an immediate, potent radical hit confined to the near-field site of application, causing localized and often irreversible biomolecular damage, followed by a sustained, programmable non-radical afterglow that diffuses to modulate signaling pathways and inflammatory responses over a broader spatial and temporal range

NRF2 cooperates with CBP/p300 to drive robust glutathione production, yet this interaction is dispensable for NRF2-dependent cancer cell growth

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Elsaman, A
