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Several potential associations have been given, excessive oxidative stress, respiratory chain abnormalities and imbalances in mitochondrial dynamics leading to mitochondrial dysfunction, as well as the fact that both endogenous and exogenous NO can induce apoptosis through mitochondria-dependent mechanisms (144)
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doi:10.1073/pnas.0900206106
Lactic acid in tumor microenvironments causes dysfunction of nkt cells by interfering with mtor signaling
2013;305:L26777
