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Bhui and co-authors explored that bromelain inhibits COX-2 expression by blocking the activation of MAPK-regulated NF-kappa B against skin tumor initiation triggering the mitochondrial death pathway (139)

Proline peptidase ( pepP and pepX ), endopeptidase ( pepE and pepF ), and dipeptidase ( pepV and pepD ) were also found in the Renuspore genome

The brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are essential and common mechanisms for the antidepressant effects of both the parent molecules of ketamines [i.e., S, R()ketamine, S(+)ketamine, and R()ketamine] and their active metabolites [i.e., (2R,6R)-hydroxynorketamine and of S(+)norketamine] (Yang et al., 2019)

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Phase I study and biomarker analysis of pyrotinib, a novel irreversible Pan-ErbB receptor tyrosine kinase inhibitor, in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer