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F.RasheedT.KumarP.SadaqatS.RayyanM.et al

Polyamines directly scavenge free radicals like hydroxyl and superoxide ions

1 Introduction Cancers are the leading cause of death worldwide, with an estimated 20 million new cases and 9.7 million deaths in 2022, among which the most common types are breast, lung, colorectal, and liver cancers (Siddiqi and Johnston, 2023

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Clinical evidence has established that elevated levels of the lipid peroxidation product 4-HNE in bronchoalveolar lavage fluid are significantly associated with poorer lung function in patients with neutrophilic asthma, underscoring its relevance as a biomarker for disease severity and potential treatment response (158)