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26 Through mediating the post-translational modification dependent on NAD + , sirtuins modulate the adaptation to the altered cellular energetic status, especially the activation of oxidative metabolism and stress resistance in mitochondria in various physiological or pathological conditions

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

This series of changes is highly consistent with pathological changes such as reduced GSH and increased oxidative stress in the SN of PD patients

Li Z, Zhang L, Wang Y, Zhu Y, Shen H, Yuan J

J., Madajewicz, S., Beach, M., Gabrail, N