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Effect of chronic administration of SN and TQ on pro-inflammatory cytokines in brain tissue concentrations Continuous exposure of rats to SN led to 2.6-fold elevation in the gene expression of NF-B, 1.78-fold elevation in concentration of Tumor necrosis factor type alpha

Critical Points: The aqueous medium used affects encapsulation efficiency and release profile

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However, preliminary results suggest that high doses of NAC, still within therapeutic margins, do not limit but increase oxidative stress in the cochlea after treatment with ototoxic drugs, which share oxidative stress-related pathogenic pathways with NIHL

The force of water hitting the powder creates foaming, which introduces air into the solution and can denature the peptide through mechanical stress