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Although these reports do not accurately reflect the role of CD36 in macrophages due to the use of global knockout mice, subsequent study by Moore and colleagues demonstrated that the activation of inflammasomes in macrophages by CD36 is an underlying mechanism (60)
Vaux EC, Taylor DJ, Altmann P, Rajagopalan B, Graham K, Cooper R, et al
Furthermore, studies in human atrial- and ventricular-programmed induced pluripotent stem cells or engineered heart tissues will allow for more long-term studies and higher throughput in elucidating LCAC pathophysiology and potential targeting strategies
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