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The most likely exchanged amino acids by SLC1A5 are asparagine, threonine, or serine, and their transport, together with glutamine, allows the entry of 12 carbon atoms into the cell, which can then be oxidized in the TCA with ATP production in the mitochondria
Together, they are studied for their synergistic effects on pulsatile GH secretion in experimental models
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Since intracellular cysteine is a rate-limiting precursor for GSH synthesis, the intracellular GSH level is regulated by the system x c activity
