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The appearance of mild-yellowish, mosaic symptoms was associated with a dramatic, 20-fold induction of defense-related genes like PR-1, chitinase and GST (Niehl et al., 2006)

Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS (2015) Neutrophil ageing is regulated by the microbiome

Abbreviations AKI: Acute kidney injury ATP: Adenosine triphosphate AdMSCs: Adipose-derived mesenchymal stem cells Ki-67: Antigen Kiel 67 Bcl2: B-cell leukemia BVN-Tb4: BVN-thymosin 4 GPX4: Glutathione peroxidase 4 CGD: Chronic granulomatous disease CRRT: Continuous renal replacement therapy DAPK1: Death-associated protein kinase 1 EPCs: Endothelial progenitor cells ERK: Extracellular signal-regulated protein kinases ESC: Endothelial stem cells FGFR: Fibroblast growth factor receptor GDM: Gestational diabetes mellitus GLI2: Glioma-Associated Oncogene Family Zinc Finger 2 HSC: Hepatic stellate cell HUVECs: Human umbilical vein endothelial cells HIF-1: Hypoxia-inducible factor 1-alpha IB: Inhibitor of nuclear factor kappa B IGF-1: Insulin like growth factor 1 receptor IL: Interleukins IL-8 mRNA: Interleukin-8 messenger Ribonucleic acid LAP: LC3-associated phagocytosis LC3-II: LC3-phosphatidylethanolamine conjugate LPS: Lipopolysaccharide LC3B: Microtubule-associated protein 1A/1B light chain 3B MAPK: Mitogen-activated protein kinase MHV-A59: Mouse hepatitis virus A59 Nrf2: Nuclear factor erythroid 2-related factor 2 NF-B: Nuclear factor kappa B NLRP3: Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 PI3K: Phosphatidylinositol 3-kinase p38: P38 mitogen-activated protein kinase ROS: Reactive oxygen species rhT4: Recombinant human thymosin 4 SeNPs: Selenium nanoparticles SOD: Superoxide dismutase TdT: Terminal deoxynucleotidyl transferase TB4: Thymosin beta-4 TLR4: Toll-like receptor TNF-: Tumor necrosis factor alpha TM: Tympanic membrane T2DM: Type 2 diabetes mellitus VEGF: Vascular endothelial growth factor VIP: Vasoactive intestinal peptide References Mohan V, Joshi S, Mithal A, Kesavadev J, Unnikrishnan AG, Saboo B, Kumar P, Chawla M, Bhograj A, Kovil R