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Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification

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The studies reviewed in Blundell et al

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172,173 In support of these findings, in vivo studies using mouse stroke models have demonstrated that ATX knockout reduces LPA levels, improves vascular permeability, enhances cerebral blood flow, and decreases infarct volume, collectively reducing HCM-associated vascular dysfunction