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Because their mechanisms do not overlap, stacking them creates a two-pronged approach: Retatrutide reduces caloric intake and boosts metabolic rate from the top down, while AOD-9604 attacks stored fat at the cellular level from the bottom up

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Additional details on analytic methods per endpoint are in Supplementary Table 4

The response was dose-dependent, with higher doses producing slightly more fat loss, though the dose-response curve flattened at higher levels (Thompson et al., 2004)

The injection is very easy to give yourself, and painless