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Description
5-Amino-1MQ is a small molecule that works by inhibiting NNMT (Nicotinamide N-methyltransferase), an enzyme that reduces NAD levels in the body

Caco-2 cells were incubated with these buffers for 2 h, and the receiver side buffer was removed for analysis by LC/MS/MS (using bucetin as an analytical internal standard)

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Key gap: no human trial has been published, and no human pharmacokinetic study is widely available
Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration