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The contribution of the NLRP3 inflammasome has been largely demonstrated in fibrotic lung diseases, including silicosis [67,212,213,214] and cystic fibrosis [215,216], but the role of the NLRP3 inflammasome is increasingly discussed in the pathogenesis of COPD or asthma, too [208,217,218]

HHcy is also connected with oxidative stress through its influence on the production of free radicals and the activity of antioxidative enzymes [1]

Compared to participants with homocysteine levels below 9.0 mol/L, those with levels of 9.011.9 mol/L had a 30% increased risk of cardiovascular death and 40% increased odds of non-cardiovascular death, and those with levels of 12.014.9 mol/L had a 110% increased risk of cardiovascular and 90% increased risk of non-cardiovascular death

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While these findings do not establish diagnostic biomarkers, they underscore the relevance of metabolic profiling in ASD and support further investigation into dietary strategies as adjunctive, individualized interventions