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Notably, phosphoglycerate kinase 1 (PGK1) K131cr, K156cr, and K220cr are significantly decreased upon hypoxia
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When comparing these results at different ages, we noticed that cytokine concentration was increasing with age, with IL-1, IL-10, IFN, and TNF being the most highly secreted in the bone marrow
Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2018, Chapter 37: Synthesis and Degradation of Amino Acids, Chapter 39: Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine
This introduces additional variability that can obscure the therapeutic signal of a novel compound
