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Figure 4 8 Translational outlook: analogs, safety liabilities, and delivery strategies Erastin has demonstrated antitumor activity in several malignancies, including gastric and colorectal cancer (69, 70), and the inflammatory, iron-loaded, oxidative microenvironment shared by many tumors and EMS provides a coherent theoretical basis for applying this strategy to EMS (71, 72)

It is normally withdrawn, mixed with the drug, and then that mixture is injected (usually intramuscularly or subcutaneously, as indicated for the drug)

Damaged mitochondria produce less energy and more oxidative waste

Sci Rep 8: 17247, 2018

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