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Upstream of NF-B has also been discussed in the IH-mediated AS

Tiwari KK, Dwivedi S, Mishra S, Srivastava S, Tripathi RD, Singh NK, Chakraborty S (2008) Phytoremediation efficiency of Portulaca tuberosa rox and Portulaca oleracea L

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This extreme form of ventilation-perfusion mismatch results in impaired alveolar gas exchange , leading to poorly oxygenated blood returning to the systemic circulation and causing hypoxemia