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Varied literature supports a decrease in microbial diversity and an increase in a leaky gut phenotype throughout T1D [68]

The RNA-binding protein SND1 binds to the 3UTR of HSPA5, destabilizing HSPA5 mRNA, thereby inhibiting GPX4 and promoting ferroptosis in osteoarthritis

As mentioned in the Introduction, there are many factors that contribute to ROS including oxygen and blue light that can penetrate the cornea and lens and induce photochemical damage 16,20

The following sections are grouped by outcome of interest, with discussion focused on meta-analyses when available, supplemented by individual studies as appropriate or when meta-analysis-level evidence does not exist

Paschke, R