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acidophilus augments the activity of tacrolimus by promoting the proliferation of SIGNR3-associated Treg and inhibiting Th17, reestablishing the balance of Th17/Treg ratios in lymphoid tissues ( B cells are equally significant components of the immune system whose formation and function are regulated by major transcription factors such as Paired Box Protein 5 (PAX5), Early B-cell Factor 1 (EBF1), E2A Transcription Factor (E2A), and Interferon Regulatory Factor 4 (IRF4)