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Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance

In the Reepithelization stage, BV triggers human epidermal keratinocyte division and migration while decreasing interleukin-8 (IL-8) and Tumor necrosis factor- (TNF-)

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