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CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability

63 Prolonged skeletal muscle inactivity promotes mitochondrial dysfunction, resulting in increase in mitochondrial ROS production and leading to protracted oxidative stress and disturbed redox signaling, 64 which can exacerbate IR through multiple pathways such as JNK and NF-B pathways (Fig

Supplementary Table S15) (Li et al., 2016a

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The shedding typically lasts 2 to 4 weeks and signals positive response
